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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Han-Qing Lin

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Open access Aug 2026

Discovery and Development of First-in-Class Cereblon-Recruiting RIPK1 Degraders

LD5095 demonstrates potent and selective RIPK1 degradation across cell lines, with rapid kinetics and sustained degradation over 72h post-washout, and exhibited favorable pharmacokinetics, including metabolic stability and an extended half-life.

Dong Lu, Xin Yu, Han-Qing Lin et al. · 1 citation

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