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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Han Sun

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2 papers indexed here

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Open access Sep 2026

Cross-talk of filter gate and lower helices drives polymodal regulation and disease in TREK channels

The TREK two-pore domain potassium channels regulate membrane excitability and respond to diverse physiological stimuli. Single-site mutations of TREK are associated with neurodevelopmental disorders and can cause pathological channel hyperactivation. Here, using the OneOPES enhanced-sampling molecular dynamics frame...

Berke Türkaydin, Valerio Rizzi, Chaimae Benkerdagh et al. · 0 citations
Open access Sep 2026

The wild-type hERG cryo-EM structure fails to support conduction and evolve toward an inactivated-like selectivity filter conformation in molecular dynamics simulations

The atomic structure of the human Ether-à-go-go–Related Gene (hERG) K+ channel has recently been resolved by cryo-electron microscopy (cryo-EM) under both high- and low-K+ conditions, in order to obtain information on the mechanism of the K+-sensitive, very rapid C-type inactivation typical of this channel. Although th...

Maria Vittoria Leonardi, A. Michelucci, Y. K. Aldakul et al. · 0 citations

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