Author

Hanting Xia

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Sep 2026

Mismatch-Engineered CRISPR Transistors for Ultra-Low-Frequency Single-Nucleotide Variant Detection

Accurate detection of low-frequency single-nucleotide variants (SNVs) in a high wild-type (WT) background remains challenging. Here, we report a mismatch-engineered CRISPR transistor (MECT) for rapid, amplification-free detection of mutant RNA. MECT integrates a Cas13a–crRNA recognition interface with a graphene fiel...

Chang Chen, Hongwenjie Ma, Han-Ting Xia et al. · Nano letters (Print) · 0 citations

Review Open access Aug 2026

Chromatin remodeling and epigenetic regulation of mesenchymal stem/stromal cells in osteoarthritis

Osteoarthritis (OA) creates a persistently hostile joint microenvironment in which inflammatory, mechanical, metabolic, oxidative, and senescence-related cues alter the behavior of mesenchymal stem/stromal cells (MSCs). These changes are not limited to short-term signaling responses, but they should not be interpreted...

Mo Wu, Cenzhuo Sheng, Han-Hao Zhang et al. · Frontiers in Genetics · 0 citations