Han-ul Kim

Structural insights into actin severing and capping by gelsolin.

Gelsolin is a calcium-dependent actin-binding protein composed of six homologous domains (G1-G6) and regulates cytoskeletal dynamics. Here, we present the 2.89 Å cryo-EM structure of two G1-G3s bound to a four-subunit actin filament fragment formed after phalloidin-stabilized filamentous-actin (F-actin) was treated wit...