Open access
Oct 2026
Forward genetics reveals a conserved CNBHD-CNBHD interface that restrains EAG channel activation to regulate sleep
KCNH voltage-gated potassium channels regulate neuronal excitability, yet how their hallmark cyclic nucleotide-binding homology domains (CNBHDs) influence channel gating to regulate behavior remains unclear. Using an unbiased forward genetic screen in Caenorhabditis elegans, we identified a gain-of-function mutation in...
Xin-Yu Huang, Sudharsan Kannan, Gail A. Robertson et al.
· PLoS Genetics · 0 citations