Targeting PGAM5-Drp1 axis modulates mitochondrial dynamics and inhibits pancreatic acinar cell necroptosis in severe acute pancreatitis
Severe acute pancreatitis (SAP) is a high-mortality disease characterized by extensive pancreatic necrosis and uncontrolled inflammation. Mitochondrial dysfunction and pancreatic acinar cells (PACs) necroptosis are critical pathological events in SAP, while the role of the mitochondrial protein phosphoglycerate m...