Han-Xiao Zhu

Extracellular matrix and perineuronal nets in neural plasticity, memory, and epileptogenesis

In the mature brain, the extracellular matrix (ECM) molecules derived from neurons and glia accumulate in spatially distinct extracellular compartments, including a diffuse interstitial matrix and condensed perineuronal nets (PNNs), where they regulate receptor mobility, ion homeostasis, cell-surface signaling, structu...