Review
Open access
Aug 2026
Branched-chain amino acid metabolism and macrophage polarization: potential regulatory nodes and therapeutic targets in diabetes-associated metabolic inflammation
T2DM is characterized by chronic low-grade metabolic inflammation, and imbalanced macrophage polarization is a key immunological mechanism contributing to insulin resistance (IR), pancreatic β-cell damage, and diabetes progression. Recent studies in immunometabolism suggest that BCAA metabolism regulates macrophage pol...
Ruili Yang, Ruodi Yang, Han Zhang et al.
· Frontiers in Cellular and In... · 0 citations