Review
Open access
Aug 2026
TREM2 signaling in cardiovascular disease: macrophage heterogeneity, timing, and therapeutic opportunity.
BACKGROUND Cardiovascular diseases remain the leading cause of global morbidity and mortality, with pathogenesis extending beyond hemodynamic derangements to involve chronic, maladaptive immune-metabolic crosstalk. Macrophage functional identity has evolved beyond the M1/M2 paradigm toward a model of high heterogeneity...
Ke Yang, Xuefang Ma, Binyan Wang et al.
· Journal of Advanced Research · 0 citations