Review
Sep 2026
Roles of JAMM-family deubiquitinase STAMBPL1 in cellular homeostasis and human cancer
Hu Lei, Han-Zhang Xu, Li Yang et al.
· Molecular Biology Reports · 0 citations
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Review
Jul 2026
Ubiquitin-specific protease 48: Molecular mechanisms, pathophysiological roles and therapeutic potential.
Current advances in USP48 structure, substrate specificity, molecular mechanisms, and disease-specific functions are synthesized to provide a critical evaluation of preclinical USP48-targeted therapeutic strategies, and delineate the major conceptual and translational challenges impeding the clinical development of USP...
Hu Lei, Chujiao Zhu, Li Yang et al.
· Biochemical and Biophysical... · 1 citation
Open access
Aug 2026
Identification of YL064 as a novel inhibitor of ATXN3 to suppress tumor growth and metastasis by promoting degradation of oncogenic substrates
YL064 is established as a promising ATXN3 inhibitor that targets the ubiquitin-proteasome pathway to exert anti-tumor effects, highlighting its potential as a novel therapeutic agent for ATXN3-driven cancers.
Zhenge Zhang, Wenhui Bai, Yayue Tan et al.
· Cell Death & Disease · 0 citations