Background: Cellular senescence is a critical driver of chronic inflammation, tissue remodeling, and progressive fibrosis during the aging process. Codonopsis tangshen Oliv. is a widely used medicinal and edible homologous plant in traditional Chinese medicine; however, its pharmacological effects on natural aging and...
Yi Zhao, Yu-Meng Gong, Han Zhu et al.· Nutrients· 0 citations
Renal tubular injury contributes substantially to the progression of acute kidney injury (AKI) and chronic kidney disease (CKD). S-palmitoylation is a reversible lipid modification that regulates protein localization, stability, trafficking, and signaling. In renal tubular epithelial cells (TECs), it supports epithelia...
Miao Li, Han Zhu, Hui-Ping Zhao et al.· Frontiers in Cell and Develo...· 0 citations
This review systematically examines the mechanisms of metabolic reprogramming in different renal cell types and highlights their contribution to renal injury, highlighting the ability of natural products to confer renal protection by modulating key regulatory nodes of metabolic reprogramming.
Wenru Wang, Han Zhu, Keqin Zhao et al.· Journal of Translational Int...· 0 citations
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