Hanadi A. Katuah

Synthesis, molecular modelling, and biological evaluation of new pyrazine-oxadiazole hybrids as anticancer agents

Three various pyrazine-oxadiazole hybrids 4a-c , 7a-c , and 10a-c were synthesized by reacting the precursor, 4-(pyrazin-2-ylamino)benzohydrazide ( 2 ), with different substituted benzoic acids, aryl isothiocyanates, where the produced thiosemicarbazides cyclized with iodine/NaOH, or aromatic aldehydes, follo...