Hang-Mao Lee

Microglia activation by derepression of endogenous retroviruses drives inflammation and cellular senescence.

Aging-associated loss of chromatin compaction is linked to derepression of retrotransposable elements (RTEs) in mouse and human tissues. Whether such RTE transcription contributes to the microglia activation that is common in aged brains is unknown. Here, we show that DAXX, a histone chaperone and RTE repressor, is dow...