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Aug 2026

Switchable Synthesis of α- or β-Keto Naphthalenes via Gold-Catalyzed Divergent Cycloisomerization of 1,6-Diyn-3-ols and Its Application in the Total Synthesis of Justicidin B and Taiwanin C.

A switchable divergent gold catalysis is described that employs 1,6-diyn-3-ols as a common starting material for the regioselective synthesis of β-keto and α-keto naphthalenes. Under Au(I) catalysis, the α-keto naphthalenes are obtained regioselectively. In contrast, the β-keto naphthalenes are obtained as the major pr...

Shuang Zang, Yan-Bin Wu, Hang Ren et al. · 0 citations

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