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Author

Hang Zhang

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Open access Oct 2026

Insights into pyrazinone biosynthesis from biochemical and cryo-EM studies of the hybrid NRPS-PKS enzyme CorA

Hybrid nonribosomal peptide synthetase-polyketide synthase (NRPS-PKS) systems integrate peptide and polyketide biosynthetic logic to assemble complex natural products. CorA, a prototypical NRPS-PKS hybrid from the myxobacterium Corallococcus exiguus SDU70, is responsible for producing 5-alkylated pyrazinones, a family...

Qing-Yu Yang, Qian Wang, Xiao-Ju Li et al. · 0 citations

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