Simultaneous HPLC-UV quantification of donepezil and rivastigmine in human plasma using an SBA-15/graphene oxide nanocomposite based DLLME dSPE approach
This study aimed to develop and validate a sensitive, environmentally friendly analytical method for the simultaneous quantification of donepezil and rivastigmine in human plasma to support therapeutic drug monitoring (TDM). The approach combined a novel dispersive solid-phase extraction (dSPE) utilizing a purposely sy...