Hannah V. Masterson

Sexual dimorphism of autism-like phenotypes in microglial eIF4E overexpression mice

It is demonstrated that sex hormones are a major determinant of the increased susceptibility of males to ASD-like phenotypes in MG4E mice and the absence of ER expression in microglia suggests that sex hormones may act indirectly through hormone- responsive neurons to regulate microglia-neuron interactions during neuro...