Single Tire-Derived Pollutant (6-PPD) Exposure Triggers Lung Injury and Mitochondrial Disruption in Mice.
N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6-PPD) is a widely used tire antiozonant that has recently emerged as a global environmental concern. Although its aquatic toxicity is well documented, its respiratory toxicity in mammals remains poorly understood. We aimed to characterize the temporal progression of...