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Author

Hao Chai

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Review Open access Jul 2026

Deciphering immunosuppressive niches by spatial single-cell proteomics: spatial interaction networks and translational opportunities

Current research findings on the cellular composition, spatial structure, and regulatory mechanisms of the immunosuppressive microenvironment are summarized and the emerging clinical value of space biomarkers and interaction networks in patient stratification, therapeutic target identification, and precision immunother...

Hao Chai, Lang Wu, Xiaopeng Chen et al. · 0 citations
Review Open access Aug 2026

Research and advances in TK1-mediated metabolic reprogramming in modulating the tumor immune microenvironment in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is still one of the leading causes of cancer-related deaths in the world. It is characterized by significant metabolic disorders and immunosuppressive tumor microenvironment(TME). As a key enzyme in the thymidine remedy pathway, TK1 is traditionally regarded as a biomarker related to pr...

Hao Chai, Lang Wu, Minghao Li · 0 citations

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