Author

Hao-Chen Zhao

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Open access Sep 2026

TMEDRP: decoding tumor-intrinsic and microenvironmental signatures for clinical drug response prediction

Abstract Motivation Clinical drug response prediction is constrained by the paucity of patient data, forcing a reliance on in vitro cell line models. Current transfer learning-based methods typically focus on learning domain-invariant representations, but often overlook the critical role of tumor microenvironment (TME)...

Ya-Bin Kuang, Hao-Chen Zhao, Yi Luo et al. · Bioinformatics · 0 citations

Open access Aug 2026

A unified framework for molecular property prediction based on hierarchical multi-granularity molecular representation learning

An atom–bond bipartite graph modeling approach that treats atoms and bonds as explicit learnable node types and jointly models atom–atom, atom–bond, and bond–bond local interactions within a unified propagation framework is introduced.

Xing Zhao, Xianlai Chen, Yunbo Wang et al. · Bioinformatics · 0 citations