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Author

Hao-Cheng Lu

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2 papers indexed here

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Oct 2026

Integrative genetic analyses for drug repurposing identify emodin as a candidate modulator of STAT3 signaling in abdominal aortic aneurysm.

Emodin is identified as a candidate modulator of AAA progression acting through suppression of STAT3-associated signaling pathways, and the potential of genetic evidence-guided drug repurposing strategies in complex vascular diseases is demonstrated.

Ying-Jie Liu, Zhi-Jun Xu, Lin Deng et al. · 0 citations
Open access Oct 2026

Macrophage-Derived Glycoprotein Nonmetastatic Melanoma Protein B Attenuates Cardiac Dysfunction by Promoting Vascular Endothelial Growth Factor-Independent Angiogenesis.

BACKGROUND Pressure overload-induced heart failure involves maladaptive cardiac remodeling and inadequate angiogenesis. The limitations of VEGF (vascular endothelial growth factor)-based therapies underscore the need to identify alternative angiogenic pathways. GPNMB (glycoprotein nonmetastatic melanoma protein B) is a...

Hai-Huan Lin, Zhi-Hui Yang, Chi Zhang et al. · 0 citations

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