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Author

Haohan Wang

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Open access Sep 2026

Stratifying Alzheimer’s disease by patient-specific genetic signatures reveals cognition-linked and cross-disease heterogeneity

A heteroscedastic personalized regression framework is introduced to move beyond cohort-averaged associations and construct individualized single-nucleotide polymorphism (SNP) profiles for each subject, showing that model-derived individualized SNP-score profiles can reveal latent structure associated with cognitive an...

Jia-Hui Zhang, Zi-Yu Yu, Xing-Cai Zhang et al. · 0 citations
Review Aug 2026

AI-powered medicinal chemistry and translational drug development.

This review examines how machine learning, deep learning, natural language processing (NLP), and generative modeling are being applied across medicinal chemistry and drug development, and highlights how multimodal data fusion, predictive modeling, and human-AI collaborative frameworks are supporting more informed decis...

Kaicheng U, Sophia Meixuan Zhang, Ziyu Yu et al. · 0 citations

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