Hao Hong

A prelimbic cortex-lateral hypothalamus circuit regulates acquisition of alprazolam-induced conditioned place preference in male mice.

An excitatory projection from ventromedial hypothalamus to lateral hypothalamus mediates stress-induced reinstatement of alprazolam-conditioned place preference in male mice.

Alprazolam (Alp) is a clinically common benzodiazepine (BZD) with a potential risk of abuse, yet the mechanisms underlying its reinstatement remain unclear. In this study, a conditioned place preference (CPP) paradigm combined with forced swim stress (FSS) was employed to induce CPP reinstatement in male mice with prio...

Deletion of Bmal1 in the Prelimbic Cortex Glutamatergic Neurons Triggers Schizophrenia-Like Behaviors in Mice.

Results reveal a previously unidentified role for Bmal1 deficiency in the PrL in driving SCZ-relevant negative symptoms and cognitive dysfunction, and provide experimental evidence supporting a putative role for dysregulated circadian clock gene expression in the pathogenesis of SCZ.