Review
Open access
Jul 2026
Microglia-mediated synaptic pruning in neural circuit remodeling: multidimensional control in homeostasis and neuropathology.
This review summarizes the mechanisms by which microglia shape synaptic structure and function, including dynamic synaptic interactions, selective pruning, epigenetic regulation, extracellular matrix remodeling, metabolic adaptation, and communication with other glial cells.
Zheng Liu, Wu-lan Ao, Ai-Di Luo et al.
· BMC Medicine · 0 citations