Synthesis of Pyrroloquinazolinones via Base-Promoted Domino Reaction of 7-Vinylindoles with In Situ Formed Isocyanates from Dioxazolones.
Herein, we report a novel base-promoted domino reaction between 7-vinylindoles and dioxazolones, enabling the efficient one-pot synthesis of pyrroloquinazolinone scaffolds in moderate to excellent yields (up to 95%). This transition-metal-free protocol employs readily available dioxazolones as isocyanate precursors and...