Author

Hao-Jie Xu

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Review Open access Sep 2026

Narrow Therapeutic Index Drugs: Regulatory Frameworks, Bioequivalence, and Model-Informed Precision Dosing

Background/Objectives: Narrow therapeutic index (NTI) drugs are characterized by a small margin between effective and toxic exposure. This review aimed to summarize international definitions and regulatory frameworks for NTI drugs, compare bioequivalence requirements for generic NTI products, and evaluate the role of m...

Meng Liu, Zhe Wang, Yong-Bo Chen et al. · Pharmaceutics · 0 citations

#data science Review Open access Oct 2026

Effect of different dietary patterns on patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials

Background Type 2 diabetes mellitus (T2DM) affects over 500 million people worldwide, and dietary management is a cornerstone of treatment. This meta-analysis descriptively evaluated the comparative efficacy and safety of four common dietary patterns—Mediterranean diet (MD), intermittent fasting (IF), energy-restricted...

Hao-Jie Xu, Hao-Tian Ma, Si-Yao Jin et al. · Frontiers in Nutrition · 0 citations