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Hao Li

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Open access Jul 2026

The ARHGAP32 isoform PX-RICS is specifically targeted to inhibitory synapses by binding to gephyrin.

Gephyrin is identified as the primary synaptic anchor for PX-RICS and the N-terminal gephyrin-binding region (GBR) engages gephyrin E-domain through conserved hydrophobic interactions, explaining the isoform-specific targeting of PX-RICS (but not RICS) to inhibitory synapses.

Guanhua Bai, Ruifeng Huang, Yinmiao Lian et al. · 0 citations