Tangeretin ameliorates sepsis-induced neurocognitive impairment in adult male mice by suppressing Akt-driven glycolytic reprogramming and neuroinflammation.
Tangeretin mitigates sepsis-associated neuroinflammation and cognitive impairment by targeting microglial Akt signalling and restraining glycolytic reprogramming and these data support tangeretin as a mechanistically informed candidate for adjunctive therapy in sepsis-related neurocognitive dysfunction.