Hao-Ling Zhang

Neutrophil plasticity in inflammation resolution: mechanisms and therapeutic potential

Programmed cell death in inflammation: interactions and holistic perspective

Programmed cell death (PCD) is a major regulatory mechanism that maintains tissue homeostasis and immune balance and strongly influences the initiation, progression and resolution of inflammation. Although apoptosis, pyroptosis, necroptosis and ferroptosis are individual PCD modes that are regulated by different molecu...

Post-translational modifications in Neuroimmune cells during neuroinflammation: integrated regulatory networks and therapeutic opportunities

Evidence is synthesized on various PTMs such as phosphorylation, ubiquitination, SUMOylation, acetylation, methylation, glycosylation, S-nitrosylation, and metabolite-coupled modifications, including lactylation and succinylation that have the potential to enhance biomarker-guided disease stratification and inform the...

Reshaping the ncRNA Regulatory Network: Decoding the Pathological Mechanisms and Novel Therapeutic Paradigms of Heart Failure.

Heart failure (HF) is a significant global health issue, and its complicated pathogenesis needs to be further clarified. In recent years, non-coding RNAs (ncRNAs) have emerged as key players in the development and pathogenesis of HF; nonetheless, their systemic regulatory networks and clinical translational capacity ne...

Protein Post-Translational Modifications in the Regulation of Ferroptosis: New Opportunities and Challenges for Cancer Immunotherapy

This paper systematically discusses the potential application value of ferroptosis-related protein PTM in overcoming tumor immune escape, enhancing the antitumor activity of T cells and natural killer cells, and improving the clinical efficacy of immune checkpoint inhibitors (ICIs).

The cGAS-STING pathway: mechanistic basis, dual biological functions and translational therapeutic advances

This review systematically investigates the distinct functional states and biological behaviors of the cGAS-STING pathway under a variety of disease conditions to provide comprehensive theoretical references and research directions for follow-up basic mechanistic studies and clinical transformation of cGAS-STING target...

Microglia and neuroinflammation: An in‐depth analysis from functional diversity to disease mechanisms

This review summarizes recent advances in microglial biology across acute brain injury, neurodegenerative and demyelinating disorders, central nervous system infections, and psychiatric and neurodevelopmental diseases and provides new opportunities for precision therapy.

Post-translational modifications in Neuroimmune cells during neuroinflammation: integrated regulatory networks and therapeutic opportunities

Neuroinflammation represents a common pathological mechanism underlying a wide range of central nervous system (CNS) disorders, encompassing neurodegenerative disorders (NDDs), ischemic stroke (IS), traumatic brain injury (TBI), and demyelinating diseases such as multiple sclerosis (MS). This process is initiated by th...