Retinoic acid alleviates manganese-induced neurotoxicity in SH-SY5Y cells via the Trim28/α-synuclein/H4K91ac epigenetic axis
Background Manganese (Mn)-induced neurotoxicity is a major public health concern. The aim of this study is to assess whether retinoic acid, a metabolite of vitamin A, can counteract manganese-induced neurotoxicity in SH-SY5Y cells by counteracting epigenetic dysregulation. Methods In vivo, we assessed neurobehavioral f...