Hao-Nan Shen

From pathogen to “living drug factory” innovative strategies and clinical translation of bacteria as programmable intelligent vectors for cancer therapy

This review systematically explores the dual roles of tumor‐associated microbiota‐both promoting and suppressing malignancy‐and highlights the transformative potential of engineered bacterial systems in cancer treatment, and discusses innovative strategies in which bacteria are harnessed to remodel the immunosuppressive tumor microenvironment, potentiate immune checkpoint therapies, and synergize with conventional modalities.