Open access
Aug 2026
A biased allosteric modulator is a molecular glue for β2AR dimerization.
Family A G-protein-coupled receptors (GPCRs) are typically described as monomers, yet growing evidence suggests that they can form dimers with distinct signalling properties1-3. However, the mechanisms and therapeutic potential of such dimerization remain poorly understood. Here we show that AP-7-168, an optimized deri...
Jiemin Shen, T. Peddada, Konstantin E. Komolov et al.
· Nature · 2 citations