Review
Open access
Oct 2026
Synthetic Biology and Systems Metabolic Engineering of Aminoglycoside Antibiotics: From Biosynthetic Pathways to Resistance-Evading and Low-Toxicity Design
Aminoglycoside antibiotics are important therapeutic agents in the clinical treatment of Gram-negative bacterial infections; however, the spread of antimicrobial resistance, together with dose-limiting ototoxicity and nephrotoxicity side effects, substantially restricts their clinical utility. Recent advances in synthe...
Shang-Ye Chu, Yu-Qing Chu, Mo-Han Huang et al.
· Microorganisms · 0 citations