Sequence variations govern the hierarchical self-assembly and structural polymorphism of PSM-α functional amyloids.
Biofilm-associated functional amyloids reinforce extracellular matrices and enhance microbial resistance to environmental and antimicrobial stresses. In Staphylococcus aureus, phenol-soluble modulins (PSMs), particularly the PSM-α family, regulate biofilm maturation and pathogenicity through sequence-dependent self-ass...