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Hao-Tian Liu

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Open access Aug 2026

A Single‐Amino‐Acid Ligand for LAT1: A Minimalist and Modular Platform for Lysosome‐Targeted Degradation of Membrane Proteins

ABSTRACT Targeted degradation of membrane proteins via the lysosomal pathway holds great therapeutic promise, yet existing platforms rely on bulky ligands such as glycopolymers, antibodies, or protein nanocages, which complicate synthesis and limit tissue penetration. Here, we repurpose L‑type amino acid transporter 1...

Li-Quan Zhu, Ke Liu, Hao-Tian Liu et al. · 1 citation

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