Developments of Quinoline-Engineered Radioligands for Melanin-Targeted PET Imaging.
A quinoline-based platform was developed to generate melanin-targeted radiotracers suitable for 68Ga-labeling. Four quinoline derivatives integrating a melanin-binding moiety and a radiometal chelator were synthesized and evaluated. All tracers exhibited high hydrophilicity (Log P -2.86 to -2.50) and good radiochemical...