Rational Design of Porphyrin-Based Nano-Prodrug for Overcoming ROS Resistance and Synergistic Photodynamic Cancer Therapy.
Porphyrin-based photosensitizers (PSs) are among the most widely explored agents for photodynamic therapy (PDT), yet their clinical translation is severely limited by poor biocompatibility, aggregation-induced quenching, insufficient tumor selectivity, and the intrinsic reactive oxygen species (ROS) resistance of cance...