Open access
Oct 2026
PAK4 exacerbates melanoma immunosuppression by promoting exosome release.
Melanoma remains a lethal malignancy with frequent resistance to immune checkpoint blockade therapy. Clinical evidence associates elevated PAK4 expression with poor response to anti-PD-1 treatment in melanoma patients. While tumor-derived exosomes are recognized as key immunosuppressive mediators, the role of PAK4 in r...
Rui-Zhi Zhou, Tong Xu, Ze-Ming Shen et al.
· Proceedings of the National... · 0 citations