Hao-Wei Li

GTPase GBP7 promotes HSV-1 infection by interacting with and activating eEF1A1 to accelerate the protein translation process.

Guanylate-binding proteins (GBPs) are immune GTPases induced by interferons (IFNs) and comprise GBPs1-7. In this study, GBP7, a less studied member of the GBPs, was identified to possess Herpes simplex virus I (HSV-1) promoting effects on replication both in vitro and in vivo. Knockdown of GBP7 or loss of its GTPase ac...