Author

Hao-Xu Wu

2 papers indexed here

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Sep 2026

circMTHFD1L-driven lipid metabolism in Cancer-associated fibroblasts confers oxaliplatin resistance in pancreatic cancer through O-GlcNAcylation-dependent chromatin recruitment of Ku70.

Platinum-based chemotherapy resistance severely limits therapeutic efficacy and survival in pancreatic ductal adenocarcinoma (PDAC), yet the role of cancer-associated fibroblasts (CAFs) in driving this resistance remains elusive. We screened and validated circMTHFD1L (hsa_circ_0078269) as a stromal circRNA that is mark...

Qing Tian, Tian-Hao Huang, Ning-Ning Zhang et al. · Cancer Letters · 0 citations

Review Open access Sep 2026

Integrated network toxicology and multiomics analyses reveal the mechanisms underlying trimethyltin chloride-induced epilepsy and the ameliorative effects of astaxanthin via NFKB1 and IL6.

Trimethyltin chloride (TMT) is a ubiquitous neurotoxic organotin pollutant that induces epilepsy, while the natural marine product astaxanthin (AST) exerts potent antioxidant, anti-inflammatory and neuroprotective effects. However, the causal molecular mechanisms of TMT-induced epilepsy and the targeted intervention me...

Ming-Ke Qin, Dao Zhou, Hao-Xu Wu et al. · Ecotoxicology and Environmen... · 0 citations