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Author

Haohong Chen

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Review Jul 2026

De novo synthesis of large-scale metabolic pathways for natural products and their optimization strategies.

This review systematically analyzes core strategies and cutting edge technologies for reconstructing large scale metabolic pathways in microbial cell factories using synthetic biology to address challenges such as metabolic burden, pathway imbalance, and host toxicity, ultimately paving the way for scalable and cost effective biosynthesis of natural product pharmaceuticals.

Jia-Yi Jiang, Jv-Liang Dai, Haohong Chen et al. · 0 citations

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