Haotong Zhang

VGLL4 enhances PDK4 transcription and promotes metabolic dysfunction-associated fatty liver disease.

MAFLD is a global epidemic with a limited number of approved targeted therapies, underscoring the urgent need to define its underlying regulatory mechanisms. Here, we identify VGLL4 as a positive regulator of MAFLD progression. Hepatocyte-specific overexpression of Vgll4 induces hepatic steatosis, insulin resistance, a...