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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Haruhisa Inoue

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Open access Aug 2026

Generation of mutant human SOD1 knock-in mouse lines at the Rosa26 locus as a platform for developing genome-editing therapies for amyotrophic lateral sclerosis.

A knock-in mouse line at the Gt(ROSA)26Sor (Rosa26) locus carrying a single-copy, 11-kb human SOD1 genomic fragment, including all exons and introns, with the L126S mutation is generated, providing a versatile and clinically relevant platform for the preclinical evaluation of genome-editing therapies targeting heterozy...

T. Okunomiya, Tomoki Sakasai, Kayoko Tsukita et al. · 0 citations
Open access Jul 2026

Neurogenesis defects in iPSC-derived midbrain organoids of early-onset Parkinson's disease with 22q11.2 deletion syndrome

These findings suggest that, in early-onset PD patients with 22q11.2 DS or PRKN mutation, enhanced neurogenesis could result in reduced number of dopaminergic neurons during early development, which indicates that the onset of PD may occur as early as the embryonic stage.

Syugo Ueki, Toshiya Kimura, Rie Tohge et al. · 0 citations

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