High-Dose MK-801 Attenuated Early TTC-Defined Cortical Injury Even under the Conditions of Suppressed Rapamycin-Sensitive pS6 Signaling during Early Cerebral Ischemia-Reperfusion.
The interrelationship of mechanistic target of rapamycin (mTOR), brain-derived neurotrophic factor (BDNF), NMDA receptor and neuronal survival during early cerebral ischemia-reperfusion is not certain. We investigated this relationship by using MK-801, a non-competitive NMDA receptor antagonist and by determining infar...