Author

Hatem A Abdel-Aziz

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Aug 2026

Striking two targets with one scaffold via benzo[d]imidazole-isatin conjugates as potent dual VEGFR-2/c-MET antagonists.

Chemical 8b may serve as a promising candidate for further anticancer research after demonstrating encouraging dual kinase inhibitory action and exhibiting a favorable selectivity profile for normal MCF-10A cells.

Mohamed El-Naggar, Rofaida Salem, Mona M. Kabeel et al. · Bioorganic & Medicinal Chemi... · 0 citations

Open access Jul 2026

In silico pipeline for GSK 3β inhibitor discovery in Alzheimer’s disease using pharmacophore screening, docking, ADME filtering, and MD validation

These findings identify SB1 and LB1 as promising, safe, and brain-penetrant GSK-3β lead compounds for experimental validation in Alzheimer’s disease.

Mahmoud S. Elkotamy, Mohamed K. Elgohary, Ahmed S. Alkotami et al. · Scientific Reports · 0 citations