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Open access Sep 2026

DEG2MOL: Conditional Latent Flow Matching for Transcriptome-Guided de novo Drug Design

Transcriptomic profiles capture cellular responses to perturbations, offering a principled foundation for biologically grounded de novo drug design. However, existing transcriptome-guided generative approaches remain limited in biological specificity, transcriptomic coverage, and evaluation across diverse perturbatio...

Songhyeon Kim, Wootaek Lim, Hawon Lee et al. · 0 citations

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