Parkinson's disease (PD) is a progressive neurodegenerative disorder of the central nervous system (CNS), driven by the pathological aggregation and accumulation of α-synuclein (α-Syn) within dopaminergic neurons of the substantia nigra pars compacta (SNpc). Despite extensive research, the pathogenesis of PD remains in...
Hayder M. Al-kuraishy, M. Naji, R. R. Abd Hasan et al.· Neurodegenerative Disease Ma...· 0 citations
A narrative review explores how platelet activation may contribute to MS through blood-brain barrier dysfunction, immune-cell recruitment, oxidative stress, demyelination, and neurodegeneration, and critically examines acetylsalicylic acid (ASA) as a potential platelet-targeted strategy.
H. Al-Jehani, Hayder M. Al-kuraishy, Weam A. Elkady et al.· Multiple Sclerosis and Relat...· 0 citations
Brain aging is driven by progressive failure of neuronal proteostasis, culminating in the accumulation of toxic protein aggregates characteristic of Alzheimer's, Parkinson's, and Huntington's diseases. The AMPK-mTOR-autophagy signaling hub integrates cellular energy status with protein clearance machinery, making it a...
H. Al-Jehani, Hayder M. Al-kuraishy, Ahmed M. Abdelaziz et al.· Molecular and cellular neuro...· 0 citations
Berberine, a naturally occurring isoquinoline alkaloid found in several medicinal plants such as Berberis spp. and Coptis chinensis has long been used in traditional medicine. Recent evidence positions berberine as a pleiotropic modulator of multiple interconnected hallmarks of aging, making it a promising candidate fo...
S. M. Alanazi, Hayder M. Al-kuraishy, Ahmed M. Abdelaziz et al.· Fitoterapia· 0 citations
Age-related cognitive decline and neurodegenerative disorders present significant challenges in neuropsychiatry, as current therapeutic strategies largely fail to adequately address the complexities of cerebral aging. Resveratrol, a natural polyphenol, has become a promising multi-target neuroprotective agent that can...
A. Al-Dhahi, Hayder M. Al-kuraishy, Mohamed N. Fawzy et al.· Progress in Neuro-psychophar...· 0 citations
PAF/PAF-R targeting remains a mechanistically promising but clinically unestablished therapeutic approach requiring further translational investigation, and some detrimental effects of PAF appear to occur independently of PAF-R.
A. Baothman, Hayder M. Al-kuraishy, Weam A. Elkady et al.· Multiple Sclerosis and Relat...· 0 citations
By integrating immunomodulatory and neuroprotective actions, α7-nAChR targeting represents a mechanistically compelling strategy for comprehensive disease modification in MS, although clinical translation remains contingent upon overcoming significant pharmacological and biomarker-related challenges.
A. Al-Dhahi, Hayder M. Al-kuraishy, Ahmed A. Mohamed et al.· Life Science· 0 citations
Overall, current evidence does not support a significant increase in ASD risk, and clinical guidelines should remain unchanged, given the known risks of alternative therapies, particularly non-steroidal anti-inflammatory drugs during pregnancy.
R. Hasanain, Hayder M. Al-kuraishy, Mustafa M. Shokr et al.· Neurotoxicology· 0 citations
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