Simple Summary Perioperative immunotherapy, which includes treatment before and after surgery, has improved outcomes for some patients with resectable non-small cell lung cancer. However, current clinical trials usually test the entire treatment plan rather than the separate value of continuing immunotherapy after surg...
Jing-Yuan Fan, Yi-Chao Han, Run-Sen Jin et al.· Cancers· 0 citations
Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications
The prognostic impact of type 2 diabetes in esophageal cancer patients receiving neoadjuvant therapy followed by surgery remains unclear. We evaluated its association with perioperative outcomes and long-term surv...
Xi-Peng Wang, Zhi-Chao Liu, Xue-Feng Leng et al.· Diseases of the esophagus· 0 citations
Bispecific antibodies (BsAbs) integrate two binding specificities to coordinate antitumor mechanisms that cannot be readily achieved with conventional monospecific antibodies. In lung cancer, these agents encompass four principal strategies: dual targeting of tumor-associated receptors, immune-cell redirection, simulta...
Ming-Yuan Du, Yi-Chao Han, Run-Sen Jin et al.· Critical reviews in oncology...· 0 citations
Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies
The clinical significance of supraclavicular lymph node (SCLN) involvement in esophageal cancer remains controversial. The role of surgery in managing patients with SCLN metastases remains uncertain. This study evaluates the prognostic outcomes of pati...
Yiheng Huang, Yuqin Cao, He-Cheng Li· Diseases of the esophagus· 0 citations
Findings identify NSUN2 as a critical orchestrator of T-cell exclusion in LUAD and serves as both a candidate predictive biomarker for ICI failure and a promising druggable target for immunotherapy resistance.
Wang-Yang Meng, Tong Lu, Ming-Yuan Du et al.· Experimental Hematology & On...· 0 citations
Regulatory T cells (Tregs) maintain immune homeostasis through FOXP3-centered transcriptional complexes that tightly control lineage stability and suppressive function. However, how specific FOXP3 mutations disturb this complex and drive pathogenic Treg reprogramming in IPEX syndrome remains unclear. We identifie...
Bin Li, Wei-Qi Zhang, Xin-Nan Liu et al.· Journal of Immunology· 0 citations