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Author

He Li

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Aug 2026

In Situ Generation of Claudin18.2-Specific CAR-T Cells via Lipid Nanoparticle-Mediated mRNA Delivery.

Chimeric antigen receptor (CAR) T-cell therapy has achieved remarkable clinical success in hematological malignancies; however, its broader application is limited by high manufacturing costs and insufficient efficacy against solid tumors. To overcome these challenges, an in situ CAR-T cell generation strategy was devel...

He Li, Jing-Yun Li, Ying Wang et al. · 0 citations
Open access Jul 2026

Triptolide targets JUN to reverse cisplatin resistance of ovarian cancer: insights from single-cell transcriptome analysis and machine learning validation

This study developed a comprehensive strategy integrating computational predictions with in vitro experimental validations that reverses CDDP resistance in PROC by downregulating JUN, which dismantles intracellular pro-survival networks.

Chen Wang, Junfeng Guo, Taiyang Ye et al. · 0 citations

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