Review
Open access
Jul 2026
The disorazole family of potent anticancer agents: structures, bioactivity, total synthesis, and heterologous biosynthesis.
This review articulates a paradigm shift in disorazole research: from confronting the extreme challenge of total chemical synthesis towards harnessing programmable biosynthetic engineering (F & Z), and highlights how key technologies have revolutionized the production and diversification of these molecules.
Guoan Fu, He Li, Ruijuan Li et al.
· Journal of Advanced Research · 0 citations